API Caffeic acid phenethyl ester synthesis compound CAS 104594-70-9 for Cancer

1. Caffeic acid phenethyl ester(104594-70-9) Description


Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

It has a role as an antineoplastic agent, an anti-inflammatory agent, an immunomodulator, a metabolite, an antioxidant, a neuroprotective agent, an antiviral agent and an antibacterial agent.

2. Caffeic acid phenethyl ester(104594-70-9) Specifications

Product Name
Caffeic acid phenethyl ester
Chemical Name
Caffeic Acid Phenethyl Ester;
Phenylethyl caffeate; Phenethyl caffeate; Caffeic acid 2-phenylethyl ester; β-Phenylethyl caffeate;
2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate
Brand Name
No data for available
Drug Class
Tyrosine Kinase Inhibitors, Inhibitors
CAS Number
104594-70-9
InChIKey
SWUARLUWKZWEBQ-VQHVLOKHSA-N
Molecular Formula
C17H16O4
Molecular Weight
284.311 g/mol
Monoisotopic Mass
284.31 g·mol−1
Melting Point 
125-126ºC (dec.)
Boiling point
498.6±45.0 °C at 760 mmHg
Biological Half-Life
No Data Available
Color
off-white
Solubility 
Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
Storage Temperature 
Store at 0°C
Caffeic acid phenethyl ester Application
Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.

3. Caffeic acid phenethyl ester (104594-70-9) video

https://vimeo.com/309395487

Comments

Post a Comment

Popular posts from this blog

Buy Conjugated linoleic acids (CLA)-Phcoker

Conjugated linoleic acids (CLA) 95% S pecifications Product Name Conjugated linoleic acids (CLA) 95% Chemical Name 9,11-Linoleic acid;9,11-Octadecadienoic acid;Conjugated Linolenic Acid,CLA;CIS-10,CIS-12-OCTADECADIENOICACID;CIS-10-CIS-12-CONJUGATEDLINOLEICACID;TRANS-10,TRANS-12-OCTADECADIENOICACID;Conjugated linoleic acid - Microencapsulated solid;Octadecadienoic Acid (Conjugic Acidd, cis-9,Trtans-11) (C18:2) Brand Name N/A Drug Class N/A CAS Number 121250-47-3 InChIKey OYHQOLUKZRVURQ-HZJYTTRNSA-N Molecular F ormula C18H32O2 Molecular W eight 280.44 Monoisotopic Mass 280.24023 g/mol Boiling point  444 to 446 °F at 16 mm Hg (NTP, 1992) F reezing P oint N/A Biological Half-Life Easily oxidized by air. Color Y ellow liquid S olubility  Freely soluble in ether; soluble in absolute alcohol; 1 mL dissolves in 10 mL petroleum ether; miscible with dimethylformamide, fat solvents, oils S torage T emperature  Store at -20° C A pplication A family of 8 geometric isomers of linoleic ...
Read more

Hydroxypinacolone Retinoate: A New Generation Of Anti-aging And Whitening Cosmetics

Image
  What is Hydroxypinacolone Retinoate ? Hydroxypinacolone Retinoate (HPR)  is a unique retinoic acid derivative and the newest member of the vitamin A family of ingredients. It is a so-called retinoic acid ester, which is directly related to retinoic acid. Different from other forms of retinoids, HPR can directly act on the skin and bind to the retinoid receptors of skin cells, it can achieve the purpose of skin care without additional transformation steps. At the same time, HPR is also one of the most bio-available, nonprescription forms of Vitamin-A sold in cosmetics and easy to formulate. Compared with other retinoid cosmetic (such as retinol, retinal, and retinyl palmitate), it is highly stable and has low irritation to the skin. Because of its function of regulating the metabolism of epidermal cells and stratum corneum, HPR is often used to reduce seborrhea, dilute epidermal pigment, prevent skin aging, prevent acne, whitening spots, etc . At present, it is mainly used fo...
Read more

Can EUK-134 Really Reduce The Damage To Skin Caused By Ultraviolet Rays?

Image
  EUK-134  overview EUK-134  is a mimic of superoxide dismutase and catalase with high antioxidant capacity. It is an extremely rare self-regenerating molecule that can scavenge superoxide free radicals, eliminate hydrogen peroxide and convert reactive oxygen species into water and oxygen. Although it has been around for many years, few products on the market use this truly outstanding antioxidant. Unlike other antioxidants, EUK 134 can regenerate itself to provide all-weather antioxidant support. That is, after removing free radicals, it will regenerate again to maintain its function and continue to scavenge other free radicals. This can protect us from premature aging of the skin, while reducing the damage to the skin caused by sunlight and ultraviolet rays. As a powerful antioxidant and a new miracle skin care ingredient, EUK-134 is currently mainly used in skin care products by cosmetic manufacturers to keep the skin young and healthy. It is worth noting that EUK-134 ...
Read more